(19)

(11)

EP 1 402 011 A2

(12)

(88) Date of publication A3: 24.12.2003 (43) Date of publication: 31.03.2004 Bulletin 2004/14 (21) Application number: 02706428.6 (22) Date of filing: 21.02.2002

(51) International Patent Classification (IPC)7: C12N 9/16, C12N 11/14 (86) International application number: PCT/US2002/005755 (87) International publication number: WO 2002/068454 (06.09.2002 Gazette 2002/36)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.02.2001 US 791138 20.02.2002 US 81737 (71) Applicant: BATTELLE MEMORIAL INSTITUTE Richland, WA 99352 (US)	(72) Inventors: ACKERMAN, Eric J Richland, WA 99352 (US) LIU,Jun Albuquerque,NM 87109 (US) CHENGHONG, Lei Richland, WA 99352 (US) (74) Representative: Brown, Fraser Gregory James et al fJ Cleveland 40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)