(19)
(11) EP 1 404 698 A2

(12)

(88) Date of publication A3:
17.04.2003

(43) Date of publication:
07.04.2004 Bulletin 2004/15

(21) Application number: 02742241.9

(22) Date of filing: 19.06.2002
(51) International Patent Classification (IPC)7: C07H 21/02, C07H 21/04, A61K 48/00, C12Q 1/68, C12N 15/85, C12N 15/86, C12P 19/34
(86) International application number:
PCT/US2002/019664
(87) International publication number:
WO 2003/000707 (03.01.2003 Gazette 2003/01)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 21.06.2001 US 888360

(71) Applicant: ISIS PHARMACEUTICALS, INC.
Carlsbad, CA 92008 (US)

(72) Inventors:
  • BENNETT, Frank, C.
    Carlsbad, CA 92008 (US)
  • DOBIE, Kenneth
    Del Mar, CA 92014 (US)

(74) Representative: Hallybone, Huw George et al
Carpmaels and Ransford,43-45 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) ANTISENSE MODULATION OF SUPEROXIDE DISMUTASE 1, SOLUBLE EXPRESSION