(19)

(11)

EP 1 404 815 A2

(12)

(88) Date of publication A3: 08.01.2004 (43) Date of publication: 07.04.2004 Bulletin 2004/15 (21) Application number: 01990388.9 (22) Date of filing: 03.11.2001

(51) International Patent Classification (IPC)7: C12N 5/08, A61K 35/14 (86) International application number: PCT/EP2001/012768 (87) International publication number: WO 2002/036751 (10.05.2002 Gazette 2002/19)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR (30) Priority: 03.11.2000 US 245168 P (71) Applicant: Kourion Therapeutics AG 40764 Langenfeld (DE)	(72) Inventor: WERNET, Peter 40627 Düsseldorf (DE) (74) Representative: Meyers, Hans-Wilhelm, Dr.Dipl.-Chem. et al Patentanwältevon Kreisler-Selting-WernerPostfach 10 22 41 50462 Köln 50462 Köln (DE)