(19)

(11)

EP 1 406 638 A2

(12)

(88) Date of publication A3: 20.02.2003 (43) Date of publication: 14.04.2004 Bulletin 2004/16 (21) Application number: 02730453.4 (22) Date of filing: 24.05.2002

(51) International Patent Classification (IPC)7: A61K 31/715 (86) International application number: PCT/GB2002/002457 (87) International publication number: WO 2002/096945 (05.12.2002 Gazette 2002/49)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 24.05.2001 GB 0112649 (71) Applicant: Isis Innovation Limited Oxford OX2 7DD (GB)	(72) Inventors: BROWN, Gordon D.,University of Oxford Oxford,Oxforshire OX1 3RE (GB) GORDON, Siamon,University of Oxford Oxford,Oxforshire OX1 3RE (GB) (74) Representative: Lord, Hilton David  MARKS & CLERK,57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)