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EP 1 406 889 A2

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(88) Date of publication A3: 20.11.2003 (43) Date of publication: 14.04.2004 Bulletin 2004/16 (21) Application number: 02784844.9 (22) Date of filing: 03.07.2002

(51) International Patent Classification (IPC)7: C07D 307/52, C07D 333/22, C07D 307/66, C07D 307/68, C07D 333/38, C07D 333/28, C07D 271/113, C07D 261/14, C07D 261/08, C07D 277/32, C07D 277/84, C07D 409/14, C07D 405/14, C07D 405/12 (86) International application number: PCT/EP2002/007536 (87) International publication number: WO 2003/006447 (23.01.2003 Gazette 2003/04)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 09.07.2001 EP 01202626 (71) Applicant: Pharmacia Italia S.p.A. 20152 Milano (IT)	(72) Inventors: MOLL, Juergen I-22070 Appiano Gentile (IT) KNAPP, Stefan I-20052 Monza (IT) DALVIT, Claudio I-20154 Milan (IT) TROSSET, Jean-Yves I-21047 Saronno (IT) SUNDSTROM, Michael S-114 60 Stockholm (SE) MANTEGANI, Sergio I-20129 Milan (IT) (74) Representative: Mazzini, Giuseppe et al Pharmacia Italia S.p.A.Patent DepartmentViale Pasteur 10 20014 Nerviano (MI) 20014 Nerviano (MI) (IT)