(19)

(11)

EP 1 408 913 A2

(12)

(88) Date of publication A3: 24.04.2003 (43) Date of publication: 21.04.2004 Bulletin 2004/17 (21) Application number: 02768349.9 (22) Date of filing: 25.07.2002

(51) International Patent Classification (IPC)7: A61K 7/00 (86) International application number: PCT/US2002/023584 (87) International publication number: WO 2003/009820 (06.02.2003 Gazette 2003/06)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR (30) Priority: 25.07.2001 US 307835 P 17.04.2002 US 373300 P (71) Applicant: Alcon, Inc. 6331 Hünenberg (CH)	(72) Inventors: CAGLE, Gerald, D. Fort Worth, TX 76116 (US) BERGAMINI, Michael, V.W. Burleson, TX 76028 (US) (74) Representative: Baldock, Sharon Claire et al BOULT WADE TENNANT,Verulam Gardens70 Gray's Inn Road London WC1X 8BT London WC1X 8BT (GB)