(19)

(11)

EP 1 408 946 A2

(12)

(88) Date of publication A3: 12.02.2004 (43) Date of publication: 21.04.2004 Bulletin 2004/17 (21) Application number: 02719311.9 (22) Date of filing: 25.03.2002

(51) International Patent Classification (IPC)7: A61K 31/19, C07C 261/00, C07C 69/76, C07C 269/00, C07C 259/04 (86) International application number: PCT/US2002/008836 (87) International publication number: WO 2002/076941 (03.10.2002 Gazette 2002/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.03.2001 US 812940 27.03.2001 US 812944 27.03.2001 US 812945 26.12.2001 US 25947 (71) Applicant: Circagen Pharmaceutical Phoenix, MD 21131 (US)	(72) Inventors: LAN-HARGEST, Hsuan-Yin Fallston, MD 21047 (US) KAUFMAN, Robert, J St. Louis, MO 63130 (US) WIECH, Norbert, L Phoenix, MD 21131 (US) (74) Representative: Mallalieu, Catherine Louise et al D. Young & Co.,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)