(19)

(11)

EP 1 409 540 A2

(12)

(88) Date of publication A3: 27.03.2003 (43) Date of publication: 21.04.2004 Bulletin 2004/17 (21) Application number: 01977175.7 (22) Date of filing: 26.09.2001

(51) International Patent Classification (IPC)7: C07K 14/68, C07K 14/685, A61K 38/34, A61P 3/04, C07K 5/107, C07K 5/08, A61K 38/04, C07D 413/06, C07D 209/18, C07D 215/12, C07F 9/32, C07F 9/30, C07C 311/47 (86) International application number: PCT/US2001/030051 (87) International publication number: WO 2002/026774 (04.04.2002 Gazette 2002/12)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 27.09.2000 US 235858 P (71) Applicant: THE PROCTER & GAMBLE COMPANY Cincinnati,Ohio 45202 (US)

(72) Inventors: EBETINO, Frank, Hallock Cincinnati, OH 45249 (US) MAZUR, Adam, W. Mason, Ohio 45040 (US) HAYES, Jeffrey, Charles West Chester, OH 45069 (US) WANG, Feng Cincinnati, OH 45241 (US) SOLINSKY, Mark, Gregory Cincinnati, OH 45208 (US) COLSON, Anny-Odile Loveland, OH 45140 (US) LIN, Qishen Loveland, OH 45140 (US) (74) Representative: Clemo, Nicholas Graham et al Procter & GamblePatent DepartmentTechnical Centres Limited,Rusham Park,Whitehall Lane Egham, Surrey TW20 9NW Egham, Surrey TW20 9NW (GB)