(19)

(11)

EP 1 409 715 A2

(12)

(88) Date of publication A3: 26.02.2004 (43) Date of publication: 21.04.2004 Bulletin 2004/17 (21) Application number: 01908832.7 (22) Date of filing: 02.02.2001

(51) International Patent Classification (IPC)7: C12Q 1/68 (86) International application number: PCT/US2001/003651 (87) International publication number: WO 2001/057175 (09.08.2001 Gazette 2001/32)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.02.2000 US 496914 27.04.2000 US 560875 02.08.2000 US 632085 (71) Applicant: Nuvelo, Inc. Sunnyvale, CA 94085 (US)

(72) Inventors: BOYLE, Bryan, J. San Francisco, CA 94116 (US) MIZE, Nancy, K. Mountain View, CA 94041 (US) ARTERBURN, Matthew, C. Pleasanton, CA 94566 (US) TANG, Y., Tom San Jose, CA 95118 (US) YEUNG, George Mountain View, CA 94043 (US) ZHOU, Ping Cupertino, CA 95014 (US) LIU, Chenghua San Jose, CA 95117 (US) ASUNDI, Vinod Foster City, CA 94404 (US) DRMANAC, Radoje, T. Palo Alto, CA 94303 (US) WANG, Menq-Yun Saratoga, CA 95070 (US) CHEN, Lichuan Sunnyvale, CA 94087 (US) YANG, Yea-Huey Milpitas, CA 95035 (US) (74) Representative: Forstmeyer, Dietmar, Dr. rer. nat., Dipl.-Chem. et al Boeters & Bauer,Bereiteranger 15 81541 München 81541 München (DE) (56) References cited: :