(19)
(11) EP 1 409 731 A2

(12)

(88) Date of publication A3:
04.12.2003

(43) Date of publication:
21.04.2004 Bulletin 2004/17

(21) Application number: 02742381.3

(22) Date of filing: 01.07.2002
(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34
(86) International application number:
PCT/US2002/020940
(87) International publication number:
WO 2003/004603 (16.01.2003 Gazette 2003/03)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 03.07.2001 US 302683 P
28.01.2002 US 58740

(71) Applicant: ISIS Pharmaceuticals, Inc.
Carlsbad, CA 92009 (US)

(72) Inventors:
  • PRAKASH, Thazha, P.
    Carlsbad, CA 92009 (US)
  • MANOHARAN, Muthiah
    Carlsbad, CA 92009 (US)

(74) Representative: Hallybone, Huw George et al
Carpmaels and Ransford,43-45 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB)

   


(54) METHODS OF MODULATING PHARMACOKINETICS OF OLIGONUCLEOTIDES