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EP 1 411 942 A1

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(43) Date of publication: 28.04.2004 Bulletin 2004/18 (21) Application number: 02746843.8 (22) Date of filing: 03.07.2002

(51) International Patent Classification (IPC)7: A61K 31/445, C07D 211/30, C07D 211/94, C07D 401/06, C07D 401/12, C07D 403/06, C07D 403/12 (86) International application number: PCT/US2002/021063 (87) International publication number: WO 2003/004027 (16.01.2003 Gazette 2003/03)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 05.07.2001 US 899794 09.01.2002 US 42582 (71) Applicant: Synaptic Pharmaceutical Corporation Paramus, NJ 07652 (US)	(72) Inventors: MARZABADI, Mohammad R. Ridgewood, NJ 07450 (US) WETZEL, John Fairlawn, NJ 07410 (US) DELEON, John, E. Nort hBergen, NJ 07047 (US) JIANG, Yu Jersey, City, NJ 07307 (US) LAGU, Bharat Hillsborough,NJ 08844 (US) LU, Kai Elmwood Park, NJ 07407 (US) (74) Representative: Kjerrumgaard, Lars Bo et al H. Lundbeck A/S,Ottiliavej 9 2500 Valby-Copenhagen 2500 Valby-Copenhagen (DK)