(19)

(11)

EP 1 412 320 A1

(12)

(43) Date of publication: 28.04.2004 Bulletin 2004/18 (21) Application number: 02742526.3 (22) Date of filing: 04.07.2002

(51) International Patent Classification (IPC)7: C07C 215/20, C07C 215/26, C07D 317/46, A61K 31/133, A61K 31/335, A61K 31/165, A61K 31/137, A61P 7/02, A61P 9/00, A61P 35/00 (86) International application number: PCT/AU2002/000884 (87) International publication number: WO 2003/004454 (16.01.2003 Gazette 2003/03)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 04.07.2001 AU PR612801 26.04.2002 AU PS196902 (71) Applicant: THE AUSTRALIAN NATIONAL UNIVERSITY Acton,Australian Capital Territory 2601 (AU)

(72) Inventors: BANWELL, Martin, Gerhardt ARANDA, Australian Capital Territory 261 (AU) LIU, Ligong SUNNYBANK, Queensland 4109 (AU) PARISH, Christopher, Richard CAMPBELL, Australian Capital Territory 2 (AU) FREEMAN, Craig, Geoffrey RIVETT, Australian Capital Territory 261 (AU) (74) Representative: Campbell, Patrick John Henry  J.A. Kemp & Co.,14 South Square,Gray's Inn London WC1R 5JJ London WC1R 5JJ (GB)