(19)

(11)

EP 1 412 389 A1

(12)

(43) Date of publication: 28.04.2004 Bulletin 2004/18 (21) Application number: 02749075.4 (22) Date of filing: 30.07.2002

(51) International Patent Classification (IPC)7: C07K 16/00, C07K 16/28, C07K 16/30, A61K 39/395, A61P 35/00, A61P 37/00 (86) International application number: PCT/GB2002/003455 (87) International publication number: WO 2003/011909 (13.02.2003 Gazette 2003/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.07.2001 GB 0118662 27.09.2001 GB 0123260 (71) Applicant: THE UNIVERSITY OF SOUTHAMPTON Southampton S017 1BJ (GB)	(72) Inventor: STEVENSON, George Telford Southampton SO17 1BJ (GB) (74) Representative: Khoo, Chong-Yee  D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)