(19)
(11) EP 1 412 526 A2

(12)

(88) Date of publication A3:
10.07.2003

(43) Date of publication:
28.04.2004 Bulletin 2004/18

(21) Application number: 02753074.0

(22) Date of filing: 28.06.2002
(51) International Patent Classification (IPC)7C12Q 1/68
(86) International application number:
PCT/EP2002/007163
(87) International publication number:
WO 2003/002762 (09.01.2003 Gazette 2003/02)
(84) Designated Contracting States:
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 29.06.2001 US 302092 P
19.02.2002 US 357891 P

(71) Applicant: Syngenta Participations AG
4058 Basel (CH)

(72) Inventors:
  • SHI, LiangTorrey Mesa Research Institute, Inc
    San Diego, CA 92121 (US)
  • LI, Bi-YuTorrey Mesa Research Institute, Inc
    San Diego, CA 92121 (US)
  • WANG, XunTorrey Mesa Research Institute, Inc
    San Diego, CA 92121 (US)

(74) Representative: Gaal, Jozsef Christopher et al
Syngenta Limited,Intellectual Property Department,Jealott's Hill International Research Station,P.O. Box 3538
Bracknell,Berkshire RG42 6YA
Bracknell,Berkshire RG42 6YA (GB)

   


(54) ENHANCED DETECTION AND DISTINCTION OF DIFFERENTIAL GENE EXPRESSION BY ENZYMATIC PROBE LIGATION AND AMPLIFICATION