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EP 1 414 499 A2

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(88) Date of publication A3: 23.08.2001 (43) Date of publication: 06.05.2004 Bulletin 2004/19 (21) Application number: 00970577.3 (22) Date of filing: 04.10.2000

(51) International Patent Classification (IPC)7: A61K 48/00, A61K 35/74, C12N 15/65, A61K 51/10, A61K 51/08, A61K 49/00, A61K 47/48, G01N 33/543, C07H 21/00, C12Q 1/02, C12Q 1/04, C12Q 1/66, C12Q 1/68, C12N 1/20, A61P 35/00 (86) International application number: PCT/US2000/027397 (87) International publication number: WO 2001/025399 (12.04.2001 Gazette 2001/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 04.10.1999 US 157620 P (71) Applicants: Vion Pharmaceuticals, Inc. New Haven, CT 06511 (US) Sloan-Kettering InstituteFor Cancer Research New York,New York 10021 (US)	(72) Inventors: BERMUDES, David, G. Wallingford, CT 06492 (US) KING, Ivan, Cheung-Lam North Haven, CT 06473 (US) BLASBERG, Ronald, G. Riverside, CT 06878 (US) TJUVAJEV, Juri, G. Stroudsburg, PA 18360 (US) (74) Representative: Stark, Amanda Jane et al Abel & Imray,20 Red Lion Street London WC1R 4PQ London WC1R 4PQ (GB) (56) References cited: :