(19)

(11)

EP 1 414 522 A2

(12)

(88) Date of publication A3: 14.08.2003 (43) Date of publication: 06.05.2004 Bulletin 2004/19 (21) Application number: 02768491.9 (22) Date of filing: 09.08.2002

(51) International Patent Classification (IPC)7: A61P 3/12, A61P 7/10, A61P 21/00, A61P 25/08, A61P 27/02, A61P 27/06, A61P 35/00, A61P 35/02, A61P 43/00, A61K 31/635, A61K 45/06, A61K 31/18, A61K 31/415, A61K 31/42, A61K 31/4188 (86) International application number: PCT/US2002/025447 (87) International publication number: WO 2003/013655 (20.02.2003 Gazette 2003/08)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 10.08.2001 US 311561 P (71) Applicant: Pharmacia Corporation St. Louis, MO 63167 (US)	(72) Inventors: O'NEAL, Janet, M. St. Louis, MO 63116 (US) MASFERRER, Jaime, L. Ballwin, MO 63011 (US) (74) Representative: Albrecht, Thomas, Dr.  Kraus & Weisert,Thomas-Wimmer-Ring 15 80539 München 80539 München (DE)