(19)
(11) EP 1 414 945 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
01.04.2009 Bulletin 2009/14

(45) Mention of the grant of the patent:
21.01.2009 Bulletin 2009/04

(21) Application number: 02755137.3

(22) Date of filing: 09.08.2002
(51) International Patent Classification (IPC): 
C12N 5/06(2006.01)
G01N 33/50(2006.01)
 C12N 5/10(2006.01)
(86) International application number:
PCT/GB2002/003675
(87) International publication number:
WO 2003/014334 (20.02.2003 Gazette 2003/08)

(54)

CELL CULTURE METHOD FOR OBTAINING PROSTATE-LIKE ACINI

ZELLKULTURMETHODE ZUR ERZEUGUNG VON PROSTATA-ÄHNLICHEN ACINI

PROCEDE DE CULTURE CELLULAIRE PERMETTANT D'OBTENIR DES ACINI DE TYPE PROSTATIQUE

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GR IE IT LI LU MC NL PT SE SK TR

(30) Priority: 09.08.2001 US 311202 P
10.08.2001 GB 0119533

(43) Date of publication of application:
06.05.2004 Bulletin 2004/19

(73) Proprietor: Procure Therapeutics Limited
York YO10 5DG (GB)

(72) Inventors:
  • LANG, Shona, The University of York
    York YO10 5YW (GB)
  • MAITLAND, Norman, The University of York
    York YO10 5YW (GB)

(74) Representative: Harrison, Michael Robert et al
Gilholm Harrison Limited Marlborough House Westminster Place York Business Park
Nether Poppleton York YO26 6RW
Nether Poppleton York YO26 6RW (GB)


(56) References cited: : 
   
  • LANG S H ET AL: "IN VITRO MODELLING OF EPITHELIAL AND STROMAL INTERACTIONS IN NON-MALIGNANT AND MALIGNANT PROSTATES" BRITISH JOURNAL OF CANCER, LONDON, GB, vol. 82, no. 4, 2000, pages 990-997, XP000915839 ISSN: 0007-0920
  • HASHIBA TAKAHUMI ET AL: "Serum-free coculture of stromal and epithelial cells from benign prostatic hyperplasia with keratinocyte growth factor." UROLOGIA INTERNATIONALIS, vol. 64, no. 4, June 2000 (2000-06), pages 209-212, XP001119416 ISSN: 0042-1138
  • COLLINS A T ET AL: "Androgen and oestrogen responsiveness of stromal cells derived from the human hyperplastic prostate: Oestrogen regulation of the androgen receptor." JOURNAL OF ENDOCRINOLOGY, vol. 143, no. 2, 1994, pages 269-277, XP001117921 ISSN: 0022-0795
  • MA YU-LIN ET AL: "Reconstruction of prostatic acinus-like structure from ventral and dorsolateral prostatic epithelial cells of the rat in three-dimensional collagen gel matrix culture." JOURNAL OF UROLOGY, vol. 157, no. 3, 1997, pages 1025-1031, XP001117923 ISSN: 0022-5347 cited in the application
  • HALL JUNE A ET AL: "Primary prostate stromal cells modulate the morphology and migration of primary prostate epithelial cells in type 1 collagen gels." CANCER RESEARCH, vol. 62, no. 1, 1 January 2002 (2002-01-01), pages 58-62, XP002220106 January 1, 2002 ISSN: 0008-5472
  • LANG SHONA H ET AL: "Experimental prostate epithelial morphogenesis in response to stroma and three-dimensional Matrigel culture." CELL GROWTH & DIFFERENTIATION, vol. 12, no. 12, December 2001 (2001-12), pages 631-640, XP001117481 ISSN: 1044-9523
  • PRICE ET AL: 'Immortalization of a human prostate stromal cell line using a recombinant retroviral approach' J. UROLOGY vol. 164, December 2000, pages 2145 - 2150, XP005554240
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).