(19)

(11)

EP 1 416 971 A1

(12)

(43) Date of publication: 12.05.2004 Bulletin 2004/20 (21) Application number: 00957486.4 (22) Date of filing: 16.08.2000

(51) International Patent Classification (IPC)7: A61K 48/00, A61K 35/00, A61K 49/00, A61K 51/00 (86) International application number: PCT/US2000/022456 (87) International publication number: WO 2001/012234 (22.02.2001 Gazette 2001/08)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.08.1999 US 374972 01.06.2000 US 585194 (71) Applicant: UAB Research Foundation Birmingham AL 35294-0111 (US)	(72) Inventors: BUCHSBAUM, Donald, J. Birmingham, AL 35205 (US) CURIEL, David, T. Birmingham, AL 35222 (US) ZINN, Kurt, R. Hoover, AL 35244 (US) ROGERS, Buck, E. Vestavia Hills, AL 35216 (US) (74) Representative: Heaton, Joanne Marie  Stevens, Hewlett & Perkins 1 St. Augustine's Place Bristol BS1 4UD Bristol BS1 4UD (GB) (56) References cited: :