(19)
(11) EP 1 417 304 A2

(12)

(88) Date of publication A3:
24.07.2003

(43) Date of publication:
12.05.2004 Bulletin 2004/20

(21) Application number: 02763248.8

(22) Date of filing: 10.07.2002
(51) International Patent Classification (IPC)7C12N 9/24, C12N 1/20, C12N 15/00
(86) International application number:
PCT/US2002/021773
(87) International publication number:
WO 2003/006645 (23.01.2003 Gazette 2003/04)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 13.07.2001 US 305446 P
15.02.2002 US 357553 P

(71) Applicant: IMCLONE SYSTEMS, INC.
New York, NY 10014 (US)

(72) Inventors:
  • BOHLEN, Peter
    New York, NY 10021 (US)
  • HICKLIN, Daniel
    Glen Ridge, NJ 07028 (US)
  • KUSSIE, Paul
    New York, NY 10282 (US)
  • LI, Yiwen
    Jersey City, NJ07310 (US)

(74) Representative: Beetz & PartnerPatentanwälte 
Steinsdorfstrasse 10
80538 München
80538 München (DE)

   


(54) METHOD AND COMPOSITION FOR INHIBITING HEPARANASE ACTIVITY