ATBECHDEDKESFRGBGRITLILUNLSEMCPTIE......FI....CY..TRBGCZEE....SK................*JDIM360 Ver 2.4 (29 Nov 2007) - 2999001/0The file contains technical information submitted after the application was filed and not included in this specification200802051418807CORRECTED EUROPEAN PATENT SPECIFICATIONB8B120080423W172deBibliographieenBibliographyfrBibliographieEP02796273.7200208242004030320040809enenen0112034820010824EP314303 P20010824US2008042320081720040519200421200705022007182006112120070502AT20070502BE20070813ES20070802SE20070502FI20070502DK20070802BG20070502NL20070502CZ20071002PT20070502SK20080423200817A01K 67/027 20060101AFI20040316BHEP deMETHODE ZUR INDUZIERUNG NEUROFIBRILLÄRER TANGLES IN TRANSGENEN TIERENenA METHOD OF INDUCING THE FORMATION OF NEUROFIBRILLARY TANGLES IN TRANSGENIC ANIMALSfrPROCEDE VISANT A INDUIRE LA FORMATION DE DEGENERESCENCES NEUROFIBRILLAIRES CHEZ LES ANIMAUX TRANSGENIQUESWO-A-99/57129LEWIS JADA ET AL: "Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein." NATURE GENETICS, vol. 25, no. 4, August 2000 (2000-08), pages 402-405, XP001097257 ISSN: 1061-4036 cited in the applicationGÖTZ JURGEN ET AL: "Tau filament formation in transgenic mice expressing P301L tau." JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 1, 5 January 2001 (2001-01-05), pages 529-534, XP002231385 ISSN: 0021-9258 cited in the applicationFRAUTSCHY S A ET AL: "EFFECTS OF INJECTED ALZHEIMER BETA AMYLOID CORES IN RAT BRAIN" PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 88, no. 19, 1991, pages 8362-8366, XP002231386 1991 ISSN: 0027-8424 cited in the applicationGAMES D ET AL: "ALZHEIMER-TYPE NEUROPATHOLOGY IN TRANSGENIC MICE OVEREXPRESSING V717F BETA-AMYLOID PRECURSOR PROTEIN" NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 373, no. 6514, 9 February 1995 (1995-02-09), pages 523-527, XP000602050 ISSN: 0028-0836GÖTZ J ET AL: "Formation of neurofibrillary tangles in P301L tau transgenic mice induced by Abeta42 fibrils" SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 293, no. 5534, 2001, pages 1491-1495, XP002224858 ISSN: 0036-8075GÖTZ JÜRGEN: "Tau and transgenic animal models." BRAIN RESEARCH REVIEWS, vol. 35, no. 3, July 2001 (2001-07), pages 266-286, XP001097292 ISSN: 0165-0173GÖTZ, Jürgen Brain and Mind Research Institute University of Sydney100 Mallett StCamperdown, NSW 2050AUNITSCH, RogerLangwisstrasse 27CH-8126 ZumikonCHCHEN, FengBreitensteinstr. 84CH-8037 ZürichCHUniversität Zürich02531091040161ep/Me/stoRämistrasse 718006 ZürichCHMeyers, Hans-Wilhelmet al00072541Patentanwälte von Kreisler-Selting-Werner Postfach 10 22 4150462 KölnDEATBEBGCHCYCZDEDKEEESFIFRGBGRIEITLILUMCNLPTSESKTREP200200949120020824enWO200301791820030306200310