(19)

(11)

EP 1 419 125 A1

(12)

(43) Date of publication: 19.05.2004 Bulletin 2004/21 (21) Application number: 02718890.3 (22) Date of filing: 31.01.2002

(51) International Patent Classification (IPC)7: C07B 55/00, C07D 453/02, C07D 453/04 (86) International application number: PCT/US2002/002962 (87) International publication number: WO 2003/011799 (13.02.2003 Gazette 2003/07)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 31.07.2001 US 919371 31.07.2001 US 23953 05.11.2001 US 10752 (71) Applicant: Brandeis University Waltham, MA 02453-2700 (US)	(72) Inventors: DENG, Li Waltham, MA 02453 (US) HANG, Jianfeng Waltham, MA 02453 (US) TANG, Liang Waltham, MA 02453 (US) (74) Representative: King, Elizabeth Caroline  Kilburn & Strode20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)