(19)

(11)

EP 1 419 250 A2

(12)

(88) Date of publication A3: 18.03.2004 (43) Date of publication: 19.05.2004 Bulletin 2004/21 (21) Application number: 02718810.1 (22) Date of filing: 28.01.2002

(51) International Patent Classification (IPC)7: C12N 15/12, C07K 14/47, C12Q 1/68, C07K 16/18, G01N 33/53 (86) International application number: PCT/US2002/000525 (87) International publication number: WO 2002/063009 (15.08.2002 Gazette 2002/33)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.02.2001 US 266359 P 21.02.2001 US 270564 P 13.07.2001 US 305058 P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)

(72) Inventors: BHATT, Ramesh, Rajani Carmel, IN 46033 (US) CALLEY, John, Nels Indianapolis, IN 46280 (US) HEUER, Josef, Georg Indianapolis, IN 46231 (US) KELEHER, Gerald, Patrick Indianapolis, IN 46280 (US) LANCASTER, Joanne, Sloan Indianapolis, IN 46268 (US) LI, Qingqin Carmel, IN 46032 (US) LU, Deshun Carmel, IN 46033 (US) MILLS, Bradley, Jay Morristown, IN 46161 (US) MISHRA, Santosh, Kumar Carmel, IN 46033 (US) PERKINS, Douglas, Raymond New Palestine, IN 46163 (US) ROWLINSON, Scott, William Indianapolis, IN 46256 (US) SMITH, Rosamund, Carol Greenfield, IN 46140 (US) SU, Eric, Wen Carmel, IN 46032 (US) WANG, He Carmel, IN 46033 (US) ZHI, Yu Indianapolis, IN 46202 (US) (74) Representative: Hiscock, Ian James  European Patent Operations,Eli Lilly and Company Limited,Lilly Research Centre,Erl Wood Manor,Sunninghill Road Windlesham GU20 6PH Windlesham GU20 6PH (GB)