(19)

(11)

EP 1 419 275 A2

(12)

(88) Date of publication A3: 04.12.2003 (43) Date of publication: 19.05.2004 Bulletin 2004/21 (21) Application number: 02763410.4 (22) Date of filing: 02.08.2002

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34, C07H 21/04 (86) International application number: PCT/US2002/024533 (87) International publication number: WO 2003/012066 (13.02.2003 Gazette 2003/07)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.08.2001 US 309646 P 02.08.2001 US 920872 06.03.2002 US 91784 (71) Applicant: Barnes, Wayne M. University City, MO 63130 (US)	(72) Inventor: Barnes, Wayne M. University City, MO 63130 (US) (74) Representative: Eyles, Christopher Thomas  W.P. THOMPSON & CO.55 Drury Lane London WC2B 5SQ London WC2B 5SQ (GB)