(19)
(11) EP 1 419 776 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION

(48) Corrigendum issued on:
01.09.2004 Bulletin 2004/36

(88) Date of publication A3:
16.06.2004 Bulletin 2004/25

(43) Date of publication:
19.05.2004 Bulletin 2004/21

(21) Application number: 04002427.5

(22) Date of filing: 25.09.2002
(51) International Patent Classification (IPC)7: A61K 31/496, C07D 215/22, A61P 25/18
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 25.09.2001 JP 2001290645
14.11.2001 JP 2001348276
27.03.2002 CA 2379005

(62) Application number of the earlier application in accordance with Art. 76 EPC:
02782507.4 / 1330249

(71) Applicant: OTSUKA PHARMACEUTICAL CO., LTD.
Chiyoda-ku Tokyo 101-8535 (JP)

(72) Inventors:
  • Bando, Takuji
    Tokushima-shi, Tokushima (JP)
  • Aoki, Satoshi
    Naruto-shi, Tokushima (JP)
  • Kawasaki, Junichi
    Itano-gun, Tokushima (JP)
  • Ishigami, Makoto
    Itano-gun, Tokushima (JP)
  • Taniguchi, Youichi
    Tokushima-shi, Tokushima (JP)
  • Yabuuchi, Tsuyoshi
    Tokushima-shi, Tokushima (JP)
  • Fujimoto, Kiyoshi
    Naruto-shi, Tokushima (JP)
  • Nishioka, Yoshihiro
    Matsushige-cho, Itano-gun, Tokushima (JP)
  • Kobayashi, Noriyuki
    Tokushima-shi, Tokushima (JP)
  • Fujimara, Tsutomu
    Naruto-shi, Tokushima (JP)
  • Takahashi, Masanori
    Tokushima-shi, Tokushima (JP)
  • Abe, Kaoru
    Tokushima-shi, Tokushima (JP)
  • Nakagawa, Tomonori
    Matsushige-cho, Itano-gun,Tokushima (JP)
  • Shinhama, Koichi
    Tokushima-shi, Tokushima (JP)
  • Utsumi, Naoto
    Muyachotateiwa, Naruto-shi, Tokushima (JP)
  • Tominaga, Michiaki
    Itano-gun, Tokushima (JP)
  • Oi, Yoshihiro
    Tokushima-shi, Tokushima (JP)
  • Yamada, Shohei
    Itano-gun, Tokushima (JP)
  • Tomikawa, Kenji
    Tokushima-shi, Tokushima (JP)

(74) Representative: HOFFMANN - EITLE 
Patent- und Rechtsanwälte Arabellastrasse 4
81925 München
81925 München (DE)

 
Remarks:
This application was filed on 04 - 02 - 2004 as a divisional application to the application mentioned under INID code 62.
 


(54) Low hygroscopic aripiprazole drug substance and processes for the preparation thereof


(57) The present invention provides low-hygroscopic forms of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.