(19)

(11)

EP 1 421 118 A1

(12)

(43) Date of publication: 26.05.2004 Bulletin 2004/22 (21) Application number: 02762875.9 (22) Date of filing: 27.08.2002

(51) International Patent Classification (IPC)7: C07K 16/28, A61K 39/395, C07K 16/46, A61P 19/02, A61P 19/10 (86) International application number: PCT/JP2002/008630 (87) International publication number: WO 2003/020768 (13.03.2003 Gazette 2003/11)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.08.2001 JP 2001257436 (71) Applicant: Sankyo Company Limited Chuo-ku,Tokyo 103-8426 (JP)	(72) Inventors: OGAWA, Yukie,c/o SANKYO COMPANY, LIMITED Tokyo 140-8710 (JP) FUKUDA, Chie,c/o SANKYO COMPANY, LIMITED Tokyo 140-8710 (JP) OHTSUKI, Masahiko,c/o SANKYO COMPANY, LIMITED Tokyo 140-8710 (JP) (74) Representative: Gibson, Christian John Robert et al MARKS & CLERK,57/60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)