(19)

(11)

EP 1 423 081 A2

(12)

(88) Date of publication A3: 11.03.2004 (43) Date of publication: 02.06.2004 Bulletin 2004/23 (21) Application number: 02739947.6 (22) Date of filing: 20.06.2002

(51) International Patent Classification (IPC)7: A61K 6/00 (86) International application number: PCT/US2002/019718 (87) International publication number: WO 2003/000191 (03.01.2003 Gazette 2003/01)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 25.06.2001 US 300734 P 06.06.2002 WO PCT/US74/00001 (71) Applicant: Depuy International Limited Beeston, Leeds LS11 8DT (GB)	(72) Inventors: THOMPSON, Jonathan Leeds LS17 5AD (GB) GOSIEWSKA, Anna Skillman, NJ 08558 (US) NIEMIEC, Susan Yardley, PA 19067 (US) DHANARAJ, Sridevi Raritan, NJ 08869 (US) (74) Representative: Belcher, Simon James et al Urquhart-Dykes & Lord,Tower House,Merrion Way Leeds LS2 8PA Leeds LS2 8PA (GB)