(19)

(11)

EP 1 423 134 A2

(12)

(88) Date of publication A3: 25.03.2004 (43) Date of publication: 02.06.2004 Bulletin 2004/23 (21) Application number: 02780789.0 (22) Date of filing: 19.03.2002

(51) International Patent Classification (IPC)7: A61K 38/00, A61K 38/17 (86) International application number: PCT/US2002/008123 (87) International publication number: WO 2002/102993 (27.12.2002 Gazette 2002/52)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.03.2001 US 277340 P 19.07.2001 US 306171 P 13.11.2001 US 331287 P (71) Applicant: Human Genome Sciences Rockville,Maryland 20850 (US)	(72) Inventors: ROSEN, Craig, A. Laytonsivlle, MD 20882 (US) RUBEN, Steven, M. Olney, MD 20832 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)