(19)
(11) EP 1 425 284 A2

(12)

(88) Date of publication A3:
27.11.2003

(43) Date of publication:
09.06.2004 Bulletin 2004/24

(21) Application number: 02798181.0

(22) Date of filing: 10.09.2002
(51) International Patent Classification (IPC)7C07D 491/04, C07D 495/04, C07D 519/00, A61K 31/505, A61P 35/00
(86) International application number:
PCT/US2002/028650
(87) International publication number:
WO 2003/022852 (20.03.2003 Gazette 2003/12)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
Designated Extension States:
LT LV RO SI

(30) Priority: 11.09.2001 US 318766 P

(71) Applicant: SMITHKLINE BEECHAM CORPORATION
PhiladelphiaPennsylvania 19101 (US)

(72) Inventors:
  • ADAMS, Jerry, Leroy,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • BRYAN, Deborah, Lynne,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • FENG, Yanhong,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • MATSUNAGA, Shinichiro,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • MAEDA, Yutaka,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • MIYAZAKI, Yasushi,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • NAKANO, Masato,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • ROCHER, Jean-Philippe,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • SATO, Hideyuki,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • SEMONES, Marcus,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • SILVA, Domingos, J.,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)
  • TANG, Jun,GlaxoSmithKline
    Research Triangle Park, NC 27709 (US)

(74) Representative: Hockley, Siân Catherine 
GlaxoSmithKlineCorporate Intellectual Property (CN9.25.1)980 Great West Road
Brentford, Middlesex TW8 9GS
Brentford, Middlesex TW8 9GS (GB)

   


(54) FURO- AND THIENOPYRIMIDINE DERIVATIVES AS ANGIOGENESIS INHIBITORS