(19)

(11)

EP 1 425 287 A1

(12)

(43) Date of publication: 09.06.2004 Bulletin 2004/24 (21) Application number: 02759374.8 (22) Date of filing: 16.08.2002

(51) International Patent Classification (IPC)7: C07F 3/04, A61K 31/22, A61K 31/40, A61K 31/47, A61K 31/351, A61K 31/404, A61K 31/4418, A61K 31/4965 (86) International application number: PCT/US2002/026012 (87) International publication number: WO 2003/016317 (27.02.2003 Gazette 2003/09)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 16.08.2001 US 312812 P 24.10.2001 US 37412 (71) Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD. 49131 Petah Tiqva (IL)	(72) Inventors: NIDDAM-HILDESHEIM, Valerie 40500 Even-Yeouda (IL) LIFSHITZ-LIRON, Revital 46322 Herzlia (IL) LIDOR-HADAS, Rami 44242 Kafar-Saba (IL) (74) Representative: Nachshen, Neil Jacob et al D Young & Co21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)