(19)
(11) EP 1 428 530 A8

(12) CORRECTED EUROPEAN PATENT APPLICATION
published in accordance with Art. 158(3) EPC

(48) Corrigendum issued on:
26.01.2005 Bulletin 2005/04

(43) Date of publication:
16.06.2004 Bulletin 2004/25

(21) Application number: 02799487.0

(22) Date of filing: 19.09.2002
(51) International Patent Classification (IPC)7: A61K 31/40, A61K 9/08, A61P 35/00, C07D 207/09
(86) International application number:
PCT/JP2002/009628
(87) International publication number:
WO 2003/026645 (03.04.2003 Gazette 2003/14)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR

(30) Priority: 20.09.2001 JP 2001286674

(71) Applicant: Teikoku Hormone Mfg. Co., Ltd.
Tokyo 108-8532 (JP)

(72) Inventors:
  • MIYAZAKI, Koichi
    Ebina-shi, Kanagawa 243-0406 (JP)
  • KEINO, Katsuyuki
    Yokohama-shi, Kanagawa 224-0021 (JP)
  • KANADA, Arihiro
    Kawasaki-shi, Kanagawa 211-0041 (JP)
  • MINAMI, Nobuyoshi
    Yokohama-shi, Kanagawa 241-0023 (JP)

(74) Representative: Albrecht, Thomas, Dr. et al
Kraus & Weisert, Thomas-Wimmer-Ring 15
80539 München
80539 München (DE)

   


(54) TETRAPEPTIDE DERIVATIVE CRYSTALS


(57) The invention provides crystals of N2-(N,N-dimethyl-L-valyl)-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino]propyl]-2-pyrrolidinyl]-1-[(S)-1-methylpropyl]- 4-oxobutyl]-N-methyl-L-valinamide or salts thereof which possess potent antitumor activity and methods for their preparation.