(19)

(11)

EP 1 429 732 A1

(12)

(43) Date of publication: 23.06.2004 Bulletin 2004/26 (21) Application number: 01952575.7 (22) Date of filing: 10.07.2001

(51) International Patent Classification (IPC)7: A61K 9/16 (86) International application number: PCT/US2001/021676 (87) International publication number: WO 2003/005991 (23.01.2003 Gazette 2003/04)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (71) Applicant: Kos Life Sciences, Inc. Miami, Florida 33131 (US)	(72) Inventors: ADJEI, Akwete, L. Bridgewater, NJ 08807 (US) ZHU, Yaping East Brunswick, NJ 08816 (US) CUTIE, Anthony, J. Bridgewater, NJ 08807 (US) (74) Representative: Forstmeyer, Dietmar, Dr. rer. nat., Dipl.-Chem. et al Boeters & Lieck,Bereiteranger 15 81541 München 81541 München (DE)