(19)

(11)

EP 1 430 026 A1

(12)

(43) Date of publication: 23.06.2004 Bulletin 2004/26 (21) Application number: 02777075.9 (22) Date of filing: 12.09.2002

(51) International Patent Classification (IPC)7: C07C 401/00, A61K 31/59, A61P 3/02, A61P 3/14 (86) International application number: PCT/EP2002/010233 (87) International publication number: WO 2003/027065 (03.04.2003 Gazette 2003/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.09.2001 US 323957 P 21.09.2001 US 323870 P (71) Applicant: F. HOFFMANN-LA ROCHE AG 4070 Basel (CH)	(72) Inventor: USKOKOVIC, Milan, Radoje Upper Montclair, NJ 07043 (US) (74) Representative: Waschbüsch, Klaus, Dr.  124 Grenzacherstrasse 4070 Basle 4070 Basle (CH)