(19)

(11)

EP 1 430 037 A1

(12)

(43) Date of publication: 23.06.2004 Bulletin 2004/26 (21) Application number: 02768748.2 (22) Date of filing: 29.08.2002

(51) International Patent Classification (IPC)7: C07D 261/20, C07F 1/04, C07F 3/00, C07F 3/04 (86) International application number: PCT/US2002/027593 (87) International publication number: WO 2003/020708 (13.03.2003 Gazette 2003/11)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.08.2001 US 316109 P 24.10.2001 US 344439 P (71) Applicant: TEVA PHARMACEUTICAL INDUSTRIES LTD. 49131 Petah Tiqva (IL)	(72) Inventors: NIDAM, Tamar 56238 Yehud (IL) MENDELOVICI, Marioara 76466 Rechovot (IL) SCHWARTZ, Eduard Rechovot (IL) WIZEL, Shlomit Petah Tiqva 49742 (IL) (74) Representative: Gallagher, Kirk James et al D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)