(19)

(11)

EP 1 430 039 A2

(12)

(88) Date of publication A3: 22.05.2003 (43) Date of publication: 23.06.2004 Bulletin 2004/26 (21) Application number: 02763686.9 (22) Date of filing: 20.09.2002

(51) International Patent Classification (IPC)7: C07D 277/34, A61K 31/425, C07D 277/20, C07D 417/12, C07D 417/14, A61P 3/10 (86) International application number: PCT/US2002/030017 (87) International publication number: WO 2003/024943 (27.03.2003 Gazette 2003/13)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.09.2001 US 961538 21.09.2001 US 961542 26.08.2002 US 228670 (71) Applicant: Aryx Therapeutics Santa Clara, CA 95050 (US)	(72) Inventors: DRUZGALA, Pascal Santa Rosa, CA 95403 (US) MILNER, Peter, G. Los Altos Hills, CA 94022 (US) PFISTER, Jurg, R. Los Altos, CA 94024 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERYBroadgate House7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)