(19)

(11)

EP 1 430 302 A2

(12)

(88) Date of publication A3: 08.04.2004 (43) Date of publication: 23.06.2004 Bulletin 2004/26 (21) Application number: 02728711.9 (22) Date of filing: 20.03.2002

(51) International Patent Classification (IPC)7: G01N 33/50, A61K 38/03, A61K 38/04, A61K 38/09, A61K 38/10 (86) International application number: PCT/US2002/011167 (87) International publication number: WO 2002/076173 (03.10.2002 Gazette 2002/40)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 21.03.2001 US 277790 P (71) Applicant: The Board of Regents of the University of Texas System Austin,Texas 78701 (US)	(72) Inventors: TAKASHIMA, Akira Coppell, TX 75019 (US) MUMMERT, Mark E. Dallas, TX 75061 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)