(19)

(11)

EP 1 432 817 A1

(12)

(43) Date of publication: 30.06.2004 Bulletin 2004/27 (21) Application number: 02742197.3 (22) Date of filing: 18.06.2002

(51) International Patent Classification (IPC)7: C12Q 1/68, C12Q 1/70, C07H 21/04, C07H 21/00, G01N 33/53, C07K 16/00 (86) International application number: PCT/US2002/019346 (87) International publication number: WO 2003/029490 (10.04.2003 Gazette 2003/15)

(84) Designated Contracting States: AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.10.2001 US 329311 P (71) Applicant: Wang, Yingjian Worcester, MA 01604 (US)	(72) Inventor: Wang, Yingjian Worcester, MA 01604 (US) (74) Representative: Jones, Graham Henry  Graham Jones & Company77 Beaconsfield Road Blackheath, London SE3 7LG Blackheath, London SE3 7LG (GB)