(19)

(11)

EP 1 432 821 A2

(12)

(88) Date of publication A3: 03.07.2003 (43) Date of publication: 30.06.2004 Bulletin 2004/27 (21) Application number: 02765065.4 (22) Date of filing: 02.10.2002

(51) International Patent Classification (IPC)7: C12Q 1/68, C07K 14/47 (86) International application number: PCT/GB2002/004445 (87) International publication number: WO 2003/029488 (10.04.2003 Gazette 2003/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 02.10.2001 GB 0123630 19.11.2001 GB 0127668 (71) Applicant: MEDICAL RESEARCH COUNCIL London W1N 4AL (GB)	(72) Inventors: RABBITTS, Pamela Cambridge CB2 2QH (GB) RABBITTS, T.H.,MRC Lab. of Molecular Biology Cambridge CB2 2QH (GB) (74) Representative: Maschio, Antonio, Dr. et al D Young & Co,21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)