(19)

(11)

EP 1 432 831 A2

(12)

(88) Date of publication A3: 23.10.2003 (43) Date of publication: 30.06.2004 Bulletin 2004/27 (21) Application number: 02796465.9 (22) Date of filing: 30.08.2002

(51) International Patent Classification (IPC)7: C12Q 1/68, C07H 21/02, C07H 21/04 (86) International application number: PCT/US2002/028471 (87) International publication number: WO 2003/018775 (06.03.2003 Gazette 2003/10)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 30.08.2001 US 316333 P 31.08.2001 CA 2356536 13.05.2002 US 380546 P (71) Applicant: Emory University Atlanta, Georgia 30322 (US)	(72) Inventors: WALLACE, Douglas, C. Atlanta, GA 30345 (US) HOSSEINI, Seyed Duluth, GA 30097 (US) MISHMAR, Dan Irvine, CA 92612 (US) RUIZ-PESINI, Eduardo Irvine, CA 92612 (US) LOTT, Marie Atlanta, GA 30345 (US) (74) Representative: Fisher, Adrian John et al Carpmaels & Ransford,43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)