(19)

(11)

EP 1 438 308 A1

(12)

(43) Date of publication: 21.07.2004 Bulletin 2004/30 (21) Application number: 02784010.7 (22) Date of filing: 17.10.2002

(51) International Patent Classification (IPC)7: C07D 453/00, C07D 487/08, C07D 498/04, C07D 519/00, C07D 451/04, C07D 471/08, A61K 31/445 // (C07D487/08, 209:00), C07D209:00,(C07D498/04, 221:00), C07D263:00,(C07D519/00, 209:00, 209:00, 221:00), C07D317:00,(C07D519/00, 209:00, 209:00, 221:00), C07D263:00, C07D519:00, C07D221:00 (86) International application number: PCT/US2002/031579 (87) International publication number: WO 2003/037896 (08.05.2003 Gazette 2003/19)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.10.2001 US 344436 P 21.12.2001 US 342674 P (71) Applicant: PHARMACIA & UPJOHN COMPANY Kalamazoo,Michigan 49001 (US)

(72) Inventors: WALKER, Daniel, P. Kalamazoo, MI 49009 (US) JACOBSEN, Eric, Jon Richland, MI 49083 (US) PIOTROWSKI, David, W. Portage, MI 49024 (US) WISHKA, Donn, G. Kalamazoo, MI 49006 (US) CORBETT, Jeffrey, W. Portage, MI 49024 (US) GROPPI, Vincent, E., Jr. Kalamazoo, MI 49006 (US) ACKER, Brad, A. Kalamazoo, MI 49009 (US) RAUCKHORST, Mark, R. Portage, MI 49024 (US) (74) Representative: Wood, David John  PFIZER LIMITED,European Patents Department,Ramsgate Road, Sandwich,Kent CT13 9NJ Sandwich,Kent CT13 9NJ (GB)