(19)

(11)

EP 1 438 323 A2

(12)

(88) Date of publication A3: 09.10.2003 (43) Date of publication: 21.07.2004 Bulletin 2004/30 (21) Application number: 02800481.0 (22) Date of filing: 03.10.2002

(51) International Patent Classification (IPC)7: C07H 21/02, A61K 39/02, A61K 39/095, A61K 39/385 (86) International application number: PCT/US2002/031726 (87) International publication number: WO 2003/028661 (10.04.2003 Gazette 2003/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 03.10.2001 US 326929 P 05.04.2002 WO PCT/US02/10869 17.04.2002 US 373547 P 13.05.2002 US 380677 P 24.09.2002 US 254438 24.09.2002 WO PCT/US02/30423 (71) Applicant: CHIRON CORPORATION EmeryvilleCalifornia 94608-2916 (US)	(72) Inventors: O'HAGAN, DerekChiron Corporation Emeryville, CA 94662 (US) VALIANTE, NicholasChiron Corporation Emeryville, CA 94662-8097 (US) (74) Representative: Marshall, Cameron John et al Carpmaels & Ransford43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)