(19)

(11)

EP 1 438 402 A2

(12)

(88) Date of publication A3: 11.03.2004 (43) Date of publication: 21.07.2004 Bulletin 2004/30 (21) Application number: 02796279.4 (22) Date of filing: 22.08.2002

(51) International Patent Classification (IPC)7: C12N 15/10, C12N 15/12, C07K 14/51, A61K 48/00, C07K 16/18, A61K 39/395, C12Q 1/68, A61K 38/17, A01K 67/027, G01N 33/68, G01N 33/50, A61K 31/70, C12N 15/11 (86) International application number: PCT/EP2002/009530 (87) International publication number: WO 2003/018799 (06.03.2003 Gazette 2003/10)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 22.08.2001 EP 01870181 22.08.2001 US 314056 P 14.02.2002 US 356935 P (71) Applicant: Galapagos Genomics N.V. 2800 Mechelen (BE)	(72) Inventors: KLAASSEN, Hubertus, Johannes, Matheus B-3020 Herent (BE) TOMME, Peter, Herwig, Maria B-9000 Gent (BE) VAN ES, Helmuth, Hendrikus, Gerardus NL-2011 ZZ HAARLEM (NL) VAN ROMPAEY, Luc B-3140 Keerbergen (BE) (74) Representative: Vernout, Robert  Arnold & Siedsma,Sweelinckplein 1 2517 GK Den Haag 2517 GK Den Haag (NL)