<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE ep-patent-document PUBLIC "-//EPO//EP PATENT DOCUMENT 1.4//EN" "ep-patent-document-v1-4.dtd">
<ep-patent-document id="EP02732758B8W1" file="EP02732758W1B8.xml" lang="en" country="EP" doc-number="1439839" kind="B8" correction-code="W1" date-publ="20100901" status="c" dtd-version="ep-patent-document-v1-4">
<SDOBI lang="en"><B000><eptags><B001EP>ATBECHDEDKESFRGBGRITLILUNLSEMCPTIESILTLVFIROMKCYALTR................................................</B001EP><B003EP>*</B003EP><B005EP>J</B005EP><B007EP>DIM360 Ver 2.15 (14 Jul 2008) -  2999001/0</B007EP><B078EP><date>20100318</date></B078EP></eptags></B000><B100><B110>1439839</B110><B120><B121>CORRECTED EUROPEAN PATENT SPECIFICATION</B121></B120><B130>B8</B130><B132EP>B1</B132EP><B140><date>20100901</date></B140><B150><B151>W1</B151><B153>84</B153><B155><B1551>de</B1551><B1552>Bibliographie</B1552><B1551>en</B1551><B1552>Bibliography</B1552><B1551>fr</B1551><B1552>Bibliographie</B1552></B155></B150><B190>EP</B190></B100><B200><B210>02732758.4</B210><B220><date>20020315</date></B220><B240><B241><date>20041108</date></B241><B242><date>20080902</date></B242></B240><B250>en</B250><B251EP>en</B251EP><B260>en</B260></B200><B300><B310>275627 P</B310><B320><date>20010315</date></B320><B330><ctry>US</ctry></B330></B300><B400><B405><date>20100901</date><bnum>201035</bnum></B405><B430><date>20040728</date><bnum>200431</bnum></B430><B450><date>20090617</date><bnum>200925</bnum></B450><B452EP><date>20090127</date></B452EP><B480><date>20100901</date><bnum>201035</bnum></B480></B400><B500><B510EP><classification-ipcr sequence="1"><text>A61K  31/4745      20060101AFI20040604BHEP        </text></classification-ipcr><classification-ipcr sequence="2"><text>A61P  35/00        20060101ALI20040604BHEP        </text></classification-ipcr><classification-ipcr sequence="3"><text>A61K  31/47        20060101ALI20040604BHEP        </text></classification-ipcr><classification-ipcr sequence="4"><text>A61K  31/138       20060101ALI20040604BHEP        </text></classification-ipcr></B510EP><B540><B541>de</B541><B542>ZUSAMMENSETZUNGEN, DIE COMBRETASTATIN UND KREBSBEKÄMPFENDES MITTEL ENTHALTEN</B542><B541>en</B541><B542>A COMBINATION COMPRISING COMBRETASTATIN AND ANTICANCER AGENTS</B542><B541>fr</B541><B542>COMBINAISON COMPRENANT DE LA COMBRETASTATINE ET DES AGENTS ANTICANCEREUX</B542></B540><B560><B561><text>EP-A- 0 731 085</text></B561><B561><text>EP-A- 1 068 870</text></B561><B561><text>WO-A-00/48591</text></B561><B562><text>NELKIN B D ET AL: "Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma." ONCOLOGY REPORTS, (2001 JAN-FEB) 8 (1) 157-60. , XP008013083</text></B562><B562><text>JONGE DE M J A ET AL: "THE DEVELOPMENT OF COMBINATION THERAPY INVOLVING CAMPTOTHECINS: A REVIEW OF PRECLINICAL AND EARLY CLINICAL STUDIES" CANCER TREATMENT REVIEWS, SAUNDERS, US, vol. 24, 1998, pages 205-220, XP002923195 ISSN: 0305-7372</text></B562><B562><text>CONROY T ET AL: "NOUVEAUX AGENTS DE CHIMIOTHERAPIE EN CANCEROLOGIE DIGESTIVE ACQUIS ET PERSPECTIVES NEW DRUGS IN GASTROINTESTINAL ONCOLOGY. CURRENT STATUS AND FUTURE DIRECTIONS" GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE, PARIS, FR, vol. 11, no. 23, November 1999 (1999-11), pages 1145-1165, XP001069281 ISSN: 0399-8320</text></B562><B562><text>OHSUMI, KOJI ET AL: "Novel Combretastatin Analogs Effective against Murine Solid Tumors: Desig and Structure-Activity Relationships" JOURNAL OF MEDICINAL CHEMISTRY (1998), 41(16), 3022-3032 , XP001109483</text></B562></B560></B500><B700><B720><B721><snm>BISSERY, Marie-Christine</snm><adr><str>5, rue Henri-Poincaré</str><city>F-94400 Vitry-sur-Seine</city><ctry>FR</ctry></adr></B721></B720><B730><B731><snm>Aventis Pharma S.A.</snm><iid>100081597</iid><irf>ST 01012</irf><adr><str>20, avenue Raymond Aron</str><city>92160 Antony</city><ctry>FR</ctry></adr></B731></B730><B740><B741><snm>Le Pennec, Magali</snm><sfx>et al</sfx><iid>100028021</iid><adr><str>Aventis Pharma S.A. 
Direction des Brevets 
Tri LEO/144 
20 Avenue Raymond Aron</str><city>92165 Antony Cedex</city><ctry>FR</ctry></adr></B741></B740></B700><B800><B840><ctry>AT</ctry><ctry>BE</ctry><ctry>CH</ctry><ctry>CY</ctry><ctry>DE</ctry><ctry>DK</ctry><ctry>ES</ctry><ctry>FI</ctry><ctry>FR</ctry><ctry>GB</ctry><ctry>GR</ctry><ctry>IE</ctry><ctry>IT</ctry><ctry>LI</ctry><ctry>LU</ctry><ctry>MC</ctry><ctry>NL</ctry><ctry>PT</ctry><ctry>SE</ctry><ctry>TR</ctry></B840><B844EP><B845EP><ctry>AL</ctry><date>20041108</date></B845EP><B845EP><ctry>LT</ctry><date>20041108</date></B845EP><B845EP><ctry>LV</ctry><date>20041108</date></B845EP><B845EP><ctry>MK</ctry><date>20041108</date></B845EP><B845EP><ctry>RO</ctry><date>20041108</date></B845EP><B845EP><ctry>SI</ctry><date>20041108</date></B845EP></B844EP><B860><B861><dnum><anum>EP2002006758</anum></dnum><date>20020315</date></B861><B862>en</B862></B860><B870><B871><dnum><pnum>WO2004037258</pnum></dnum><date>20040506</date><bnum>200419</bnum></B871></B870><B880><date>20040728</date><bnum>200431</bnum></B880></B800></SDOBI>
</ep-patent-document>
