(19)

(11)

EP 1 443 860 A2

(12)

(88) Date of publication A3: 24.12.2003 (43) Date of publication: 11.08.2004 Bulletin 2004/33 (21) Application number: 02801659.0 (22) Date of filing: 07.10.2002

(51) International Patent Classification (IPC)7: A61B 10/00, A61B 5/00, A61B 8/00 (86) International application number: PCT/US2002/031983 (87) International publication number: WO 2003/032900 (24.04.2003 Gazette 2003/17)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 17.10.2001 US 981206 (71) Applicant: Mallinckrodt Inc. St. Louis,Missouri 63134 (US)	(72) Inventors: ACHILEFU, Samuel, I. St. Louis, MO 63044 (US) RAJAGOPALAN, Raghavan Woodmere Village, OH 44122 (US) BUGAJ, Joseph, E. St. Charles, MO 63303 (US) DORSHOW, Richard, B. St. Louis, MO 63146 (US) (74) Representative: Cockerton, Bruce Roger et al Carpmaels & Ransford,43-45 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)