PEPTIDE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF

(19)

(11)

EP 1 445 262 A8

(12)	CORRECTED EUROPEAN PATENT APPLICATION
	published in accordance with Art. 158(3) EPC

(48)	Corrigendum issued on:
	27.10.2004 Bulletin 2004/44

(43)	Date of publication:
	11.08.2004 Bulletin 2004/33

(21)	Application number: 02780081.2

(22)	Date of filing: 14.11.2002

(51)	International Patent Classification (IPC)⁷: C07K 5/023, C12N 9/99, A61K 38/55, A61P 1/02

(86)	International application number:
	PCT/JP2002/011860

(87)	International publication number:
	WO 2003/042237 (22.05.2003 Gazette 2003/21)

(84)	Designated Contracting States:
	AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
	Designated Extension States:
	AL LT LV MK RO SI

(30)

Priority:

16.11.2001 JP 2001352012

(71)	Applicant: TAIHO PHARMACEUTICAL CO., LTD.
	Tokyo 101-0054 (JP)

(72)	Inventors:
	YAMAMOTO, Kenji Fukuoka-shi, Fukuoka 811-0215 (JP) SUDA, Yoshimitsu Tokorozawa-shi, Saitama 359-1142 (JP) ASAO, Tetsuji Kokubunji-shi, Tokyo 185-0024 (JP)

(74)	Representative: Müller-Boré & Partner Patentanwälte
	Grafinger Strasse 2 81671 München 81671 München (DE)

(54)	PEPTIDE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF

(57) The present invention provides a peptide derivative of formula (I) or a pharmaceutically acceptable salt thereof wherein X is -CH(OH)- or -CO-; R¹ is hydrogen or an amino protecting group; R² is hydroxyl or lower alkoxy; one of R³ and R⁴ is the side chain (R group) of lysine the amino group of which may be protected with a protecting group and the other of R³ and R⁴ is the side chain (R group) of arginine the guanidino group of which may be protected with a protecting group; and R⁵ and R⁶ may be the same or different and are hydrogen, lower alkyl or aralkyl. The present invention further provides a production process and use thereof.