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(11)

EP 1 446 014 A2

(12)

(88) Date of publication A3: 18.12.2003 (43) Date of publication: 18.08.2004 Bulletin 2004/34 (21) Application number: 02800391.1 (22) Date of filing: 01.10.2002

(51) International Patent Classification (IPC)7: A01N 63/00, A01N 65/00, A01N 43/04, A61K 48/00, A61K 31/70, C12N 15/00, C12N 15/09, C12N 15/63, C12N 15/70, C12N 15/74, C12N 15/85, C12N 15/87 (86) International application number: PCT/US2002/031078 (87) International publication number: WO 2003/029414 (10.04.2003 Gazette 2003/15)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 01.10.2001 US 326354 P (71) Applicant: Emory University Atlanta, Georgia 30322 (US)	(72) Inventors: GLASS, Jonathan, D. Atlanta, GA 30309 (US) RICH, Mark, M. Decatur, GA 30033 (US) (74) Representative: Weiss, Wolfgang, Dipl.-Chem. Dr. et al Weickmann & WeickmannPatentanwältePostfach 86 08 20 81635 München 81635 München (DE)