(19)

(11)

EP 1 446 502 A2

(12)

(88) Date of publication A3: 31.07.2003 (43) Date of publication: 18.08.2004 Bulletin 2004/34 (21) Application number: 02776053.7 (22) Date of filing: 27.09.2002

(51) International Patent Classification (IPC)7: C12Q 1/68, C12P 19/34, G01N 33/566, C07K 1/00, C12N 1/00, C07H 21/04, C07H 21/00 (86) International application number: PCT/US2002/031073 (87) International publication number: WO 2003/027640 (03.04.2003 Gazette 2003/14)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 28.09.2001 US 325828 P 27.03.2002 WO PCT/US02/09691 (71) Applicant: UNIVERSITY OF DELAWARE Newark, DE 19716-1551 (US)	(72) Inventors: KMIEC, Eric, B. Landenburg, PA 19350 (US) RICE, Michael, C. Newtown, PA 18940 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)