(19)
(11) EP 1 447 666 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
12.09.2012 Bulletin 2012/37

(45) Mention of the grant of the patent:
25.07.2012 Bulletin 2012/30

(21) Application number: 04396007.9

(22) Date of filing: 03.02.2004
(51) International Patent Classification (IPC): 
G01N 33/533(2006.01)
C07D 401/14(2006.01)
 C07D 401/12(2006.01)
C07F 5/00(2006.01)

(54)

Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use

Mit lumineszierenden Lanthanidchelaten markierte, biospezifisch bindende Reaktanden und ihre Verwendung

Réactifs pour liaison biospécifique marqués par des chélates luminescents de lanthanides et leur utilisation

(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR

(30) Priority: 13.02.2003 US 365637

(43) Date of publication of application:
18.08.2004 Bulletin 2004/34

(60) Divisional application:
10183588.2 / 2367001

(73) Proprietor: DHR Finland Oy
20750 Turku (FI)

(72) Inventors:
  • Takalo, Harri
    20360 Turku (FI)
  • Rosenberg, Jaana
    21420 Lieto (FI)

(74) Representative: Hjelt, Pia Dorrit Helene 
BORENIUS & Co Oy Ab Itämerenkatu 5
00180 Helsinki
00180 Helsinki (FI)


(56) References cited: : 
EP-A- 0 649 020
EP-A- 0 967 205
WO-A1-93/11433
 EP-A- 0 770 610
EP-A- 1 152 010
   
  • LEMMETYINEN H ET AL: "A time-resolved study of the mechanism of the energy transfer from a ligand to the lanthanide(III) ion in solutions and solid films" LUMINESCENCE (CHICHESTER), vol. 15, no. 6, November 2000 (2000-11), pages 341-350, XP002284751 ISSN: 1522-7235
  • TAKALO H ET AL: "DEVELOPMENT OF LUMINESCENT TERBIUM(III) CHELATES FOR PROTEIN LABELLING: EFFECT OF TRIPLET-STATE ENERGY LEVEL" HELVETICA CHIMICA ACTA, VERLAG HELVETICA CHIMICA ACTA. BASEL, CH, vol. 80, no. 2, 1997, pages 372-387, XP009026448 ISSN: 0018-019X
  • MUKKALA V-M ET AL: "Synthesis and luminescence properties of some Eu(III) and Tb(III) chelate labels having 2,2':6',2@'-terpyridine as an energy absorbing part" JOURNAL OF ALLOYS AND COMPOUNDS, ELSEVIER SEQUOIA, LAUSANNE, CH, vol. 225, 15 July 1995 (1995-07-15), pages 507-510, XP004072023 ISSN: 0925-8388
  • KARSILAYAN HURIYE IIKKA HEMMILA ET AL: "Influence of coupling method on the luminescence properties, coupling efficiency, and binding affinity of antibodies labeled with europium(III) chelates" BIOCONJUGATE CHEMISTRY, vol. 8, no. 1, 1997, pages 71-75, XP002284752 ISSN: 1043-1802
  • LODE VON P ET AL: "A EUROPIUM CHELATE FOR QUANTITATIVE POINT-OF-CARE IMMUNOASSAYS USING DIRECT SURFACE MEASUREMENT" ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 75, no. 13, 1 July 2003 (2003-07-01), pages 3193-3201, XP001175740 ISSN: 0003-2700
  • Latva et al: (1997) J. Luminescence 75, 149-169.
  • Hemmila et al: (1997) J. Alloys & Compounds 249, 158-162.
  • Takalo et al: (1994) Bioconj. Chem. 5, 278-282.
  • Mikola et al: (1995) Bioconj. Chem. 6, 235-241.
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).