(19)
(11) EP 1 448 183 A2

(12)

(88) Date of publication A3:
16.10.2003

(43) Date of publication:
25.08.2004 Bulletin 2004/35

(21) Application number: 02780564.7

(22) Date of filing: 01.11.2002
(51) International Patent Classification (IPC)7: A61K 31/198
(86) International application number:
PCT/US2002/035203
(87) International publication number:
WO 2003/043616 (30.05.2003 Gazette 2003/22)
(84) Designated Contracting States:
AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR
Designated Extension States:
AL LT LV MK RO SI

(30) Priority: 16.11.2001 US 333263 P

(71) Applicant: ALS Therapy Development Foundation, Inc.
Newton, MA 02459 (US)

(72) Inventors:
  • TENNORE, Ramesh, M.
    Westwood, MA 02090 (US)
  • SCOTT, Sean
    San Francisco, CA 94132 (US)

(74) Representative: Lock, Graham James 
Fry Heath & Spence ,The Gables,Massetts Road
Horley,Surrey RH6 7DQ
Horley,Surrey RH6 7DQ (GB)

   


(54) TREATMENT OF NEURODEGENERATIVE DISORDERS THROUGH THE MODULATION OF THE POLYAMINE PATHWAY