(19)

(11)

EP 1 448 204 A1

(12)

(43) Date of publication: 25.08.2004 Bulletin 2004/35 (21) Application number: 02802290.3 (22) Date of filing: 08.10.2002

(51) International Patent Classification (IPC)7: A61K 31/55, A61K 9/00, A61K 9/14, A61K 9/20, A61K 47/26, A61P 11/02, A61P 11/06, A61P 27/02 (86) International application number: PCT/EP2002/011250 (87) International publication number: WO 2003/037350 (08.05.2003 Gazette 2003/19)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 26.10.2001 DE 10152973 (71) Applicant: Boehringer Ingelheim International GmbH 55216 Ingelheim am Rhein (DE)	(72) Inventors: WADA, Koichi KAWABE-GUN, Hyogo 666-0257 (JP) NAKATANI, Manabu KAWANISHI, Hyogo 666-0037 (JP) OHKI, Toshimitsu IKEDA, Osaka 563-0043 (JP) TOYOSHIMA, Kenzo IKOMA, Nara 630-0254 (JP)