(19)

(11)

EP 1 448 583 A2

(12)

(88) Date of publication A3: 24.06.2004 (43) Date of publication: 25.08.2004 Bulletin 2004/35 (21) Application number: 02747073.1 (22) Date of filing: 19.07.2002

(51) International Patent Classification (IPC)7: C07H 21/04, C07K 14/705, C12N 15/09, C12N 15/63 (86) International application number: PCT/US2002/023208 (87) International publication number: WO 2003/008560 (30.01.2003 Gazette 2003/05)

(84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LI LU MC NL PT SE SK TR Designated Extension States: AL LT LV MK RO SI (30) Priority: 20.07.2001 US 306434 P 26.10.2001 GB 0125704 (71) Applicant: Aventis Pharmaceuticals, Inc. Bridgwater, New Jersey 08807-2854 (US)	(72) Inventors: EISHINGDRELO, Haifeng Montville, NJ 07045 (US) CAI, Jidong Whippany, NJ 07981 (US) ARDATI, Ali Basking Ridge, NJ 07920 (US) SANDRASAGRA, Anthony Princeton, NJ 08540 (US) (74) Representative: Bouvet, Philippe  Aventis Pharma S.A.Direction des Brevets,Tri LEO/14420, avenue Raymond Aron 92165 Antony Cedex 92165 Antony Cedex (FR)